This bispecific antibody was generated by fusion of the R73-producing 
  hybridoma with the CC52-producing hybridoma (Beun et al., 1993).
  Quadroma clones producing functional bispecific antibodies were selected 
  by testing the ability of the quadroma products to induce T cells  to lyse the 
  appropriate  tumor cells.

  R73xCC52 consists for one half of an antibody that is directed against  the rat 
  aß-T cell receptor and for the other half of an antibody directed  against an 
  antigen present on tumor cells of epithelial origin. Specific  information about 
  the reactivity of R73 and CC52 can be found elsewhere on this website.

  The bispecific antibodies induce lysis of appropriate tumor cells by  rat T cells 
  (Beun et al., 1993) and are, therefore, extremely useful to test the lytic capability 
  of rat cytotoxic T cells.

  Beun GD, Van De Velde CJ, Fleuren GJ (1993) T-cell retargeting using bispecific 
  monoclonal antibodies in a rat colon carcinoma model: III. Activation of resting 
  T cells and tumor neutralization induced by bispecific antibodies. J Immunother 
  13: 223-231